Research Interests

Prof. Beki KAN

  • Regulation of protein synthesis under oxidative stress
  • Role of G proteins and second messengers in hemin-induced erythroid differentiation
  • Heterotrimeric G proteins and GPCR Signaling
  • Purification, characterization and structural Analysis of recombinant Goα,
  • Role of G Protein mutations and polymorphisms in disease
  • Role of GPCRs and autophagy in neurodegeneration and neuroinflammation
  • Orphan GPCRs

Assoc. Prof. Devrim Öz Arslan

  • Investigation of the role of autophagy in neurodegeneration using cellular and animal models.
  • Monitoring mitochondrial dynamics and mitophagy in diseases and normal physiology.
  • Effects of membrane lipid sources on mitochondrial dynamics.
  • Protein-protein interactions.
  • Autophagy in antigen presenting cells.
  • GPCR-mediated signal transduction.

Assoc. Prof. Zeynep Aslıhan Durer

  • Recombinant protein production and purification.
  • Protein structure and function.
  • Conformational and structural analysis of proteins.
  • Biochemical and biophysical analysis of macromolecular interactions.
  • Cell cytoskeleton and focal adhesion complexes.
  • Functional and structural proteomics.

Asst. Prof. Evren Kılınç

  • Investigation of extrinsic and intrinsic blood coagulation pathways in experimental animal models and in-vitro (holder of international article 9 "certificate of experimental animal use").
  • Calibrated automated thrombinoscope (CAT) and other clinical coagulation and thrombosis tests
  • Development of atherosclerosis in Apo E - / - and LDL r - / - mouse models and pathological evaluation of the plaques formed.
  • Development, validation and troubleshooting of Direct and Sandwich ELISA analysis kits.
  • Two-photon, confocal and fluorescence microscope imaging; immunochemistry and immunofluorescence
  • Blood rheology (blood and plasma viscosity, erythrocyte deformability, platelet aggregation)

Selected works

  1. J Thromb Haemost. 2011 Jul;9(7):1359-67.

Factor XII activation is essential to sustain the procoagulant effects of particulate matter

E Kilinç, R Van Oerle, J I Borissoff, C Oschatz, M E Gerlofs-Nijland, N A Janssen, F R Cassee, T Sandström, T Renné, H Ten Cate, H M H Spronk PMID: 21481175 DOI: 10.1111/j.1538-7836.2011.04280.x

  1. Circulation. 2010 Aug 24;122(8):821-30.

Early atherosclerosis exhibits an enhanced procoagulant state

Julian Ilcheff Borissoff , Sylvia Heeneman, Evren Kilinç, Peter Kassák, René Van Oerle, Kristien Winckers, José W P Govers-Riemslag, Karly Hamulyák, Tilman M Hackeng, Mat J A P Daemen, Hugo ten Cate, Henri M H Spronk PMID: 20697022 DOI: 10.1161/CIRCULATIONAHA.109.907121

  1. Clin Hemorheol Microcirc. 2010;44(1):35-41.

Plasma viscosity and mean platelet volume in patients undergoing coronary angiography

Kubilay Senen, Ergun Topal, Evren Kilinc, Hugo ten Cate, Ibrahim Tek, Yunus Karakoc, Ertan Yetkin PMID: 20134091 DOI: 10.3233/CH-2010-1249

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