Prof. Beki KAN
- Regulation of protein synthesis under oxidative stress
- Role of G proteins and second messengers in hemin-induced erythroid differentiation
- Heterotrimeric G proteins and GPCR Signaling
- Purification, characterization and structural Analysis of recombinant Goα,
- Role of G Protein mutations and polymorphisms in disease
- Role of GPCRs and autophagy in neurodegeneration and neuroinflammation
- Orphan GPCRs
Assoc. Prof. Devrim Öz Arslan
- Investigation of the role of autophagy in neurodegeneration using cellular and animal models.
- Monitoring mitochondrial dynamics and mitophagy in diseases and normal physiology.
- Effects of membrane lipid sources on mitochondrial dynamics.
- Protein-protein interactions.
- Autophagy in antigen presenting cells.
- GPCR-mediated signal transduction.
Assoc. Prof. Zeynep Aslıhan Durer
- Recombinant protein production and purification.
- Protein structure and function.
- Conformational and structural analysis of proteins.
- Biochemical and biophysical analysis of macromolecular interactions.
- Cell cytoskeleton and focal adhesion complexes.
- Functional and structural proteomics.
Asst. Prof. Evren Kılınç
- Investigation of extrinsic and intrinsic blood coagulation pathways in experimental animal models and in-vitro (holder of international article 9 "certificate of experimental animal use").
- Calibrated automated thrombinoscope (CAT) and other clinical coagulation and thrombosis tests
- Development of atherosclerosis in Apo E - / - and LDL r - / - mouse models and pathological evaluation of the plaques formed.
- Development, validation and troubleshooting of Direct and Sandwich ELISA analysis kits.
- Two-photon, confocal and fluorescence microscope imaging; immunochemistry and immunofluorescence
- Blood rheology (blood and plasma viscosity, erythrocyte deformability, platelet aggregation)
Selected works
- J Thromb Haemost. 2011 Jul;9(7):1359-67.
Factor XII activation is essential to sustain the procoagulant effects of particulate matter
E Kilinç, R Van Oerle, J I Borissoff, C Oschatz, M E Gerlofs-Nijland, N A Janssen, F R Cassee, T Sandström, T Renné, H Ten Cate, H M H Spronk PMID: 21481175 DOI: 10.1111/j.1538-7836.2011.04280.x
- Circulation. 2010 Aug 24;122(8):821-30.
Early atherosclerosis exhibits an enhanced procoagulant state
Julian Ilcheff Borissoff , Sylvia Heeneman, Evren Kilinç, Peter Kassák, René Van Oerle, Kristien Winckers, José W P Govers-Riemslag, Karly Hamulyák, Tilman M Hackeng, Mat J A P Daemen, Hugo ten Cate, Henri M H Spronk PMID: 20697022 DOI: 10.1161/CIRCULATIONAHA.109.907121
- Clin Hemorheol Microcirc. 2010;44(1):35-41.
Plasma viscosity and mean platelet volume in patients undergoing coronary angiography
Kubilay Senen, Ergun Topal, Evren Kilinc, Hugo ten Cate, Ibrahim Tek, Yunus Karakoc, Ertan Yetkin PMID: 20134091 DOI: 10.3233/CH-2010-1249
